Select Publications

Prakash P, Manchanda P, Paouri E, Bisht K, Sharma K, Rajpoot J, Wendt V, Hossain A, Wijewardhane PR, Randolph CE, Chen Y, Stanko S, Gasmi N, Gjojdeshi A, Card S, Fine J, Jethava KP, Clark MG, Dong B, Ma S, Crockett A, Thayer EA, Nicolas M, Davis R, Hardikar D, Allende D, Prayson RA, Zhang C, Davalos D, Chopra G. (2025). Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease. Immunity, 58(6):1536–1552.e8.



Gonzalez Ibanez F, Halvorson T, Sharma K, McKee C, Carrier M, Picard K, Vernoux N, Bisht K, Deslauriers J, Lalowski M, Tremblay ME. (2023). Ketogenic diet changes microglial morphology and the hippocampal lipidomic profile differently in stress susceptible versus resistant male mice upon repeated social defeat. Brain, Behavior, and Immunity, 114:383–406

Bisht K*, Okojie KA*, Sharma K*, Lentferink DH, Sun YY, Chen HR, Oweru JO, Amancherla S, Calcuttawala Z, Campos-Salazar AB, Corliss B, Jabbour L, Benderoth J, Friestad B, Milla WA III, Isakson BE, Tremblay ME, Kuan CY, Eyo UB. (2021). Capillary-associated microglia regulate vascular structure and function through PANX1–P2RY12 coupling in mice. Nature Communications, 12:5289. (*equal contribution)



Sharma K*, Bisht K*, Eyo UB. (2021). A comparative biology of microglia across species. Frontiers in Cell and Developmental Biology, 9:652748. (*equal contribution)

Picard K*, Bisht K*, Poggini S*, Garofalo S, Golia MT, Basilico B, Abdallah F, Albanese NC, Amrein I, Vernoux N, Sharma K, Hui CW, Savage JC, Limatola C, Ragozzino D#, Maggi L#, Branchi I#, Tremblay ME#. (2021). Microglial glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice. Brain, Behavior, and Immunity, 97:423–439. (*,# equal contribution)



Sharma K, Wu LJ, Eyo UB. (2020). Calming neurons with a microglial touch. Trends in Neurosciences, 43:197–199.Sharma K, Tremblay ME. (2020). Microglia: Multiple states and multiple roles in the normal and diseased brain and spinal cord. Neuroscience Letters, 731:135019.

Bisht K, Sharma K, Eyo UB. (2020). Precise brain mapping to perform repetitive in vivo imaging of neuro-immune dynamics in mice. Journal of Visualized Experiments, (162).

Madore C, Leyrolle Q, Morel L, Rossitto M, Greenhalgh AD, Delpech JC, Martinat M, Bosch-Bouju C, Bourel J, Rani B, Lacabanne C, Thomazeau A, Hopperton KE, Beccari S, Sere A, Aubert A, De Smedt-Peyrusse V, Lecours C, Bisht K, Fourgeaud L, Gregoire S, Bretillon L, Acar N, Grant NJ, Badaut J, Gressens P, Sierra A, Butovsky O, Tremblay ME, Bazinet RP, Joffre C, Nadjar A, Layé S. (2020). Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain. Nature Communications, 11:6133.

Hui CW, Vecchiarelli HA, Gervais E, Luo X, Michaud F, Scheefhals L, Bisht K, Sharma K, Topolnik L, Tremblay ME. (2020). Sex differences of microglia and synapses in the hippocampal dentate gyrus of adult mouse offspring exposed to maternal immune activation. Frontiers in Cellular Neuroscience, 14:558181.

Gonzalez Ibanez F, Picard K, Bordeleau M, Sharma K, Bisht K, Tremblay ME. (2019). Immunofluorescence staining using IBA1 and TMEM119 for microglial density, morphology and peripheral myeloid cell infiltration analysis in mouse brain. Journal of Visualized Experiments, (152).

Hui CW, Bhardwaj SK, Sharma K, Joseph AT, Bisht K, Picard K, Tremblay ME, Srivastava LK. (2019). Microglia in the developing prefrontal cortex of rats show dynamic changes following neonatal disconnection of the ventral hippocampus. Neuropharmacology, 146:264–275.

El Hajj H, Savage JC, Bisht K, Parent M, Vallières L, Rivest S, Tremblay ME. (2019). Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology. Journal of Neuroinflammation, 16:87.

Bisht K, Sharma K, Tremblay ME. (2018). Chronic stress as a risk factor for Alzheimer’s disease: Roles of microglia-mediated synaptic remodeling, inflammation, and oxidative stress. Neurobiology of Stress, 9:9–21.

Acharjee S, Verbeek M, Gomez CD, Bisht K, Lee B, Benoit L, Sharkey KA, Benediktsson A, Tremblay ME, Pittman QJ. (2018). Reduced microglial activity and enhanced glutamate transmission in the basolateral amygdala in early CNS autoimmunity. Journal of Neuroscience, 38:9019–9033.

Henry MS, Bisht K, Vernoux N, Gendron L, Torres-Berrio A, Drolet G, Tremblay ME. (2018). Delta opioid receptor signaling promotes resilience to stress under the repeated social defeat paradigm in mice. Frontiers in Molecular Neuroscience, 11:100.

Garofalo S, Porzia A, Mainiero F, Di Angelantonio S, Cortese B, Basilico B, Pagani F, Cignitti G, Chece G, Maggio R, Tremblay ME, Savage JC, Bisht K, Esposito V, Bernardini G, Seyfried T, Mieczkowski J, Stepniak K, Kaminska B, Santoni A, Limatola C. (2017). Environmental stimuli shape microglial plasticity in glioma. eLife, 6:e33415

Tian L, Hui CW, Bisht K, Tan Y, Sharma K, Chen S, Zhang X, Tremblay ME. (2017). Microglia under psychosocial stressors along the aging trajectory. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 79:27–39.

Tay TL, Savage JC, Hui CW, Bisht K, Tremblay ME. (2017). Microglia across the lifespan: from origin to function in brain development, plasticity and cognition. Journal of Physiology, 595:1929–1945.

Stamatiades EG, Tremblay ME, Bohm M, Crozet L, Bisht K, Kao D, Coelho C, Fan X, Yewdell WT, Davidson A, Heeger PS, Diebold S, Nimmerjahn F, Geissmann F. (2016). Immune monitoring of trans-endothelial transport by kidney-resident macrophages. Cell, 166:991–1003.

Milior G, Lecours C, Samson L, Bisht K, Poggini S, Pagani F, Deflorio C, Lauro C, Alboni S, Limatola C, Branchi I, Tremblay ME, Maggi L. (2016). Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress. Brain, Behavior, and Immunity, 55:114–125.

Bisht K, El Hajj H, Savage JC, Sánchez MG, Tremblay ME. (2016). Correlative light and electron microscopy to study microglial interactions with β-amyloid plaques. Journal of Visualized Experiments, (112).

Tremblay ME, Zhang I, Bisht K, Savage JC, Lecours C, Parent M, Titorenko V, Maysinger D. (2016). Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells. Journal of Neuroinflammation, 13:116.

Bisht K, Sharma KP, Lecours C, Sánchez MG, El Hajj H, Milior G, Olmos-Alonso A, Gómez-Nicola D, Luheshi G, Vallières L, Branchi I, Maggi L, Limatola C, Butovsky O, Tremblay ME. (2016). Dark microglia: A new phenotype predominantly associated with pathological states. Glia, 64(5):826–839.



Bisht K, Sharma K, Lacoste B, Tremblay ME. (2016). Dark microglia: Why are they dark? Communicative & Integrative Biology, 9:e1230575.

Pandey K*, Sharma KP*, Sharma SK. (2015). Histone deacetylase inhibition facilitates massed pattern-induced synaptic plasticity and memory. Learning & Memory, 22:514–518. (*equal contribution)



Sharma KP, Singh JB, Sharma SK. (2014). Mechanisms of cAMP-induced sustained activation of extracellular signal-regulated kinase in the hippocampus. NeuroReport, 25:470–474.

Maharana C, Sharma KP, Sharma SK. (2013). Feedback mechanism in depolarization-induced sustained activation of extracellular signal-regulated kinase in the hippocampus. Scientific Reports, 3:1103.

Maharana C, Sharma KP, Sharma SK. (2010). Depolarization induces acetylation of histone H2B in the hippocampus. Neuroscience, 167:354–360.